… Embryo samples 2 and 5: Sven and Olaf. We have two normal embryos!! I AM SO RELIEVED.
H and I were so nervous – especially H. Normally it’s me, but this time he was pacing up and down the waiting room, so we excused ourselves and got a coffee and some fresh air before taking a deep breath, walking back into the clinic and our appointment.
Funny enough, our two normal embryos are two of the day 6 embryos (BB quality), the stragglers, and not the one which looked to be of best quality (a day 5 AB quality embryo). Elsa and Anna are out of the game (and so is Kristof). This makes me think that if we had not done PGS testing, the day 5 AB embryo would have been transferred on day 5 and would have either not implanted or I would have miscarried again. I find this fascinating.
Today is a BIG day: we find out if H and I have managed to produce any genetically normal embryos.
After three failed IVF rounds and no embryos in the freezer, we were (naturally) starting to suspect that there might be an egg quality issue. We have tested H’s Sperm numerous times, including performing a DNA fragmentation test, which showed that his sperm contain a whopping 98% normal DNA!! Considering my age, 38, only approx. 30% of my eggs are likely to be normal (the age range of 37-38: 30%-40% of eggs are normal). My AMH is 10.4 (down from 13.2 last year ☹) and shows low-ish fertility for my age, so the odds aren’t great – if 30% of my eggs are normal I’ll take it! This fact sucks, but it’s reality and we have to work with what we have. As an aside, I wish that someone had told the younger me about the reality of rapid declining fertility after 35 (it is NOT a myth)…
So, what is PGS testing?
I didn’t write an update regarding my little chicks as I had planned to on day 5 because as Ronan Keating so nicely put it “Life is a Rollercoaster”. On day 5, the rollercoaster took me up high and then, 30 minutes later, threw me back down low.
The high: the embryologist called to let us know that we had two hatched blastocysts (grades AB and BB). These two little embryos were the best looking, highest grade embryos H and I had ever produced. In IVF round 2 and The Disaster Round (round 3), we only ever produced BC quality embryos and no hatched blastocysts on day 5. A few cells from each embryo have been sent off to a lab for PGS testing, and Elsa and Anna went off to the winter wonderland [a.k.a. the freezer] for their for their beauty sleep. Saturday’s straggler had degenerated, so it is our of the game. The three remaining embryos were still developing on day 5, so the embryologist said she’d take a look at them again that afternoon and on the following day, day 6. She hoped that at least one of the three would develop into a blastocyst. I did a little happy dance.
The Low: 30 minutes after the embryologist called, my dad called. He asked if I had any news about the embryos and I delightedly told him about our two blastocysts. Sadly, that wasn’t why he had called. He wanted to let me know he had been diagnosed with bowel cancer. My world crashed.
We expected the embryologist to call with an update around 9-10am this morning. I was glued to the phone, ringer on the highest volume. Waiting, waiting, waiting. Why is it that when you’re waiting for a call those hours, minutes seem so long? I’ve never been particularly patient – but if there is one thing this fertility process
has taught me is trying to teach me, it’s to be patient.
To distract myself I met a dear friend and her toddler for coffee and a walk in the park. And, of course, as soon as I stepped out of the house at 11.30am the lovely embryologist called. All six embryos are still in the race. We have five embryos with 6-12 cells, and out of those three beautiful front-runners (perfectly formed with little to no fragmentation). The sixth little runner is struggling and the embryologist doubts it make it to the finish line, but said she wouldn’t disqualify it from the race yet.
On my NHS rounds, I never got a day 3 update, which I fully appreciate is due to lack of resource. After The Disaster Round, I requested a copy of my file so that I could give the history and the data to my new clinic. We had to pay an administration fee of £50 to obtain the notes and it took 21 days – and of course when H turned up on the 22nd day, they still hadn’t copied the notes. Anyway, bygones…
The lovely embryologist called this morning with an update. One of the eggs collected had been immature, so the embryologist had performed ICSI on eight and six of them fertilized. That’s a 75% fertilization rate – above average – and the embryologist called this an EXCELLENT fertilization rate. BOOM! I am happy. H is happy. We are back in the game, baby!
Now, we just need these little chicks to keep developing into beautiful blastocysts. When I was little kid, I had a vivid imagination. I had some cool imaginary friends (in addition to my human similarly-aged friends, I should add) called Mingan and Mangan. My grandmother will recount endless stories of me (age 2) chatting away to these friends. At that young age, I (obviously) didn’t know that talking to Mingan and Mangan would be great training for my future self (age 38) when connecting with my little chicks in a petri dish. Currently, I’m whispering the following in a soft, motherly voice:
“Hello my six little chicks. You’re in the best possible place to develop into strong and healthy embryos and go on to be beautiful babies. You focus on dividing your cells at a normal rate and enjoy yourselves while you’re at the lovely lab. I’m ready to receive you when the time is right.”
I’ve been repeating this little pep talk a few times today and will continue repeating it. I believe in positive affirmations, and I’ve used them on and off during my fertility journey (and I’ll write more about that another day). They don’t work for everyone – and I do think it takes practice (whether or not you’ve had imaginary friends!) – but they work for me. They help me refocus and look forward, which has an extraordinary effect of calming me when I feel anxious. When I was pregnant I felt connected to my embryo because it was growing inside me. It’s hard to feel connected to your embryos when you’re doing IVF because sometimes I feel like I’m just going through the motions, going from appointment to appointment, from injection to injection… So, chatting to my embryos makes me feel connected to them. And, it reminds me of the end game: to chat to my [real life] baby.
Good night my six little chicks 🐣🐣🐣🐣🐣🐣,
I’m sitting in the garden in the sunshine. I am loving this (atypical) British Summer. Despite being born in the very north of Sweden, close to the Arctic Circle, on a cold (-30 Celsius) January day, I am a summer child. I’m soaking up the rays and the vitamin D spray is firmly placed in a drawer (a very risky move when it comes to British Summer).
We got nine eggs this morning and although I was gunning for a dozen (read here), I am very happy with nine little beauties. WHOOP!! Egg collection was a smooth process – I feel a little slow and woozy from the anaesthesia but on the whole I am in no pain and I feel calm and relaxed. In The Disaster Round when we got five eggs and my lining was dire, I woke up after egg collection crying uncontrollably. Today, I feel good.
Although the consultant doesn’t normally work for the IVF clinic on Wednesdays, he popped down especially (from his private clinic) to do my egg collection this morning. Just before the anaesthetist gave me the “G&T” and sent me off to la-la land, the consultant appeared wearing a frog-clad bandana, which put a BIG smile on my face. By the way, is it only me or do you also find that every single anaesthetist says “and here comes the G&T….” before giving you the anaesthetic? I’ve been put to sleep 12 times over the past three years (!!) and every single one of them said the same thing, I swear. The head nurse who has been our primary contact during stimulation also popped down minutes before egg collection, just to wish me luck. It’s those little things that make you feel supported.
Today is day 11 of stimulation and I had an ultrasound scan this morning. There are seven follicles on the right ovary measuring between 15-22mm in diameter and four follicles on the right measuring between 19-26mm in diameter. There is also one more on the right ovary which is measuring 13mm in diameter and could possibly have a growth-spurt and reach 15mm by egg collection.
That’s a dozen in total, so I’m singing [in my head] my own version of The Pointer Sisters: “I’m so eggcited, I just can’t hide it…”
The blood work came back showing that the estrogen levels are up too, so we’re ready to go: double-trigger LH shots (Gonasi 5000 IU and Suprecur 1 mg) this evening – bam! – and collection scheduled for Wednesday, 8.30am. In my previous three rounds, I triggered with a single shot of Ovitrelle 250 mcg but in this round our consultant wants to try a double LH trigger in the hope that more eggs mature. Lucky egg collection is not on Friday because: “what’s the eggs worst day?”….. “fry-day”. (I just realised that I had egg collection on a Friday in The Disaster Round. That explains a lot.)